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KMID : 0616120080390030260
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 3 p.260 ~ p.264
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Antioxidative Constituents from the Whole Plants of Euphorbia supina
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Hong Hyun-Kyung
Kwak Jong-Hwan
Kang Se-Chan
Lee Jong-Wook
Park Jong-Hyuk
Ahn Jong-Woong
Kang Hye-Sook
Choung Eui-Su
Zee Ok-Pyo
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Abstract
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Eight compounds were isolated from the EtOAc soluble fraction of Euphorbia supina MeOH extract as the radical scavengers for antioxidant activity. Their structures were identified as kaempferol (1), quercetin (2), juglanin (3), avicularin (4), astragalin (5), isoquercitrin (6), hyperin (7), and nicotiflorin (8) by spectroscopic analysis. The antioxidant activity was evaluated by the ORAC (oxygen radical absorbance capacity) assay, which measures scavenging activity against peroxy radicals induced by 2,2’-azobis (2-methylpropionamidine) dihydrochloride, and the ORAC value is expressed as relative trolox equivalent. Compounds 4, 6, and 7 exhibited potent antioxidant activity, whereas the other compounds showed weaker activity than trolox.
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KEYWORD
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Euphorbia supina, flavonoid, antioxidant activity, ORAC assay
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